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The executive summary makes that strategy explicit by contrasting the reported event burden for the nominated peptides with higher adverse-event frequencies reported in the literature for approved peptide and protein therapeutics such as insulin, somatotropin, semaglutide, and tirzepatide

PubMed: 17904615 Safety and Tolerability of AOD 9604 in Obese Subjects: Analysis of Adverse Events Across Multiple Trials review Liu X, Manzella D, Ng FM, et al

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